Molecular Mechanism for Genetic Recombination

Molecular mechanism for genetic recombination.

Symmetry considerations of proteinnucleic acid interaction suggest the existence of an alternate branched configuration for DNA induced by binding specific structural proteins to symmetrically arranged polynucleotide base sequences. The concept that such sequences exist at the ends of genes or operons leads to a molecular model for genetic recombination in eukaryotic cells.

Molecular basis for genetic recombination.

HE past few decades have witnessed the successive description in biochemiTcal-or “molecular”-terms of the great formal entities of classical genetics. The lickage group was early identified with the objectively seen chromosome, then the gene itself, in its wild and mutant forms, more and more closely related to the linear DNA regions thereof. We have seen the identification of the gene product ...

Genetic recombination and molecular evolution.

Reduced rates of genetic recombination are often associated with reduced genetic variability and levels of adaptation. Several different evolutionary processes, collectively known as Hill-Robertson (HR) effects, have been proposed as causes of these correlates of recombination. Here, we use DNA sequence polymorphism and divergence data from the noncrossing over dot chromosome of Drosophila to d...

The Mechanism of Genetic Recombination in Phage.

Modification for the Mechanism of Retroviral Recombination

Figure 1: The original minus strand exchange model. (A) The retroviral virion contains two essentially identical RNA molecules. (B) An extended singlestranded DNA molecule is left tailing behind. This single-stranded DNA tail is free to form a hybrid duplex with another RNA molecule. (C) The original template will be displaced by branch migration of the second RNA. This second RNA molecule will...